Fed up with her parents' bickering, poor-little-rich-girl Maya (Dylan Penn) moves in with her boyfriend who is squatting in an old, condemned building on Manhattan's Lower East Side. With neighbors that are meth heads, junkies and degenerates, this depraved hell hole is even more toxic than it appears: After a virus born from their combined noxious waste and garbage infects the building's residents, one by one, they succumb to a terrifying pathogen that turns them into bloodthirsty, rampaging killers and transforms their building into a savage slaughterhouse.

Best friends Derek and Clif set out on a trip of lifetime. Their plan: travel to the ends of the earth, see the world, and live life to the fullest. But the trip soon takes a dark and bloody turn. Just days in, one of the men shows signs of a mysterious affliction which gradually takes over his entire body and being. Now, thousands of miles from home, in a foreign land, they must race to uncover the source before it consumes him completely. Footage meant to be travel memories may now become evidence of one of the most shocking discoveries ever captured on film...and perhaps will be their only postcard home.